What is the treatment for the endocrine system? Treatment may involve: Medication to rebalance hormones and treat symptoms. Chemotherapy and/or radiation therapy for patients with cancerous tumors of the endocrine gland. Surgery to remove a tumor on a gland that is affecting hormone production. Treats hormonal imbalances and disorders such as diabetes, thyroid issues, and disorders of the adrenal glands, pituitary, and other endocrine systems.